Police received reports of 12 men huddled together in an alleyway off Seabrook Road on Friday.
One was suspected of having a knife.
Writing on Facebook, the north Manchester division of GMP detailed how one of the group ran off as a police patrol arrived at the scene.
One of the two officers gave chase and he was followed onto Ludgate Road, Lambeth Road, Ballantine Street, Dymchurch Street and onto Amos Avenue.
He was detained and arrested on Culcheth Lane, GMP said.
No age has been revealed and the quantity of cannabis has not been revealed.
But police said a screwdriver was found on his possession.
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“GMP received reports of approximately 12 males congregating in an alleyway off Seabrook road in the Newton Heath area,” read the post.
“It was reported that one of the males had been seen with a small metal object, potentially a knife.
“Patrols arrived and one suspected male made off on foot.
“The offender was apprehended on the corner of Culcheth Lane. The male was arrested and found to be in possession of Cannabis and a screwdriver.
“Cannabis seized, destroyed and off the streets.”