Ms. Sethi and Mr. Zatko did not immediately respond to requests for comment.
Mr. Agrawal, who was appointed Twitter’s chief executive in November, has shuffled the company’s executives since taking over from Jack Dorsey, a founder. In December, Mr. Agrawal reorganized the leadership team and dismissed Dantley Davis, the chief design officer, and Michael Montano, the head of engineering.
Mr. Zatko and Ms. Sethi joined Twitter in late 2020. He is a well-known hacker and has had a long career in government and private industry. Before taking on his role at Twitter, he held roles at DARPA, Google and Stripe. He began his cybersecurity career in the 1990s, when he was a member of the hacking group Cult of the Dead Cow. He was recruited to Twitter after teenagers compromised the company’s systems in July 2020 and took over high-profile users’ accounts.
Ms. Sethi also joined Twitter after the hack and, alongside Mr. Zatko, was charged with improving the company’s security and protecting its user data. She was previously a vice president of information security at I.B.M. and had worked in security at Intuit and Walmart.
Lea Kissner, Twitter’s head of privacy engineering, will become the company’s interim chief information security officer, according to current and former employees. They previously held security and privacy leadership roles at Google and Apple.